Report on Activities of COST action P9
RADAM 2004-5
Scientific Progress
A full scientific review is in preparation for the mid term
review of the Action at the RADAM06 Meting to be held in Groningen,
Netherlands 6th-9th June. There have been several notable scientific advances
by members of the RADAM Community in 2004-5.
WG1 The Action’s study of electron impact with biomolecules
has received particular attention with several PRL publications from Institut
fuer Ionenphysik, Leopold Franzens Universitaet and Frei Universitaet Berlin on
dissociative attachment to nucleotide bases receiving coverage in the
international media. A complementary theoretical calculation (performed byLa
Sapienza University Rome) on the dynamics of Uracil fragmentation after electron
attachment has likewise been published in PRL and received widespread publicity.
These results provide significant consequences for the molecular description of
genotoxic effects in living cells due to low-energy electrons, which are found
to be the most abundant secondary species formed from ionizing radiation.
Several other groups have (or are) developing these studies using STSMs to visit
one another and transfer techniques and skills (e.g. Open university in the UK,
Aarhus University Denmark, New University of Lisbon , CSIC Madrid and Charles
University Prague). The development of this research field was progressing
rapidly and several of their partners had received National funding to develop
this work. All WG1 members stressed the advantages of a forum for discussion of
ideas and interchange of staff provided by STSMs.
WG2 In similar way to WG1 had developed a series of
collaborative projects with Groningen, Queens University of Belfast and GNIL
Caen cooperating on ion impact studies of nucleotide bases and, co-operating
with HMI Berlin and ATOMKI Hungary, in the study of ion induced fragmentation of
water. Several joint publications were in preparation. The collaborative work in
Groningen had also led to the exciting potential observation of Watson-Crick
pair in clusters of the nucleotide bases. Once again the ability to co-ordinate
such work through STSMs was highlighted.
WG3 had encouraged a wide variety of visits and collaborations
in several areas of Radiation damage including free radical chemistry, protein
damage and DNA damage studies as well as several in vivo experiments. Several
publications were now appearing that would not have occurred without the
incentive and opportunity for joint research led by the COST Action. WG3 team
members had also been in contact with major US groups who expressed their
admiration for the COST Action and sought to find ways to take part.
WG4 had supported several exchanges and there was now a
growing programme to explore and develop computational methods for calculating
the electronic states of biomolecules and studying biomolecular fragmentation
patterns under different ionizing radiations. This work was also allowing
interpretation of experimental results in WG1 and WG2.
WG5 was the smallest of the WGs and had been less active in
2004 in part because it required data from WG1-4 before it could develop its
models. The role of low energy electrons in promoting DNA damage was being
investigated and electron transport in DNA highlighted as a topic for further
investigation.
|